iPierian is a pioneering biopharmaceutical company that is taking the cutting-edge technologies of cellular reprogramming and directed differentiation to an entirely new level to harness the power of induced pluripotent stem cells to advance the understanding of human diseases and accelerate the discovery of more effective therapeutics for patients.
iPierian has built one of the most qualified teams of stem cell scientists in the world, combining the expertise of the founding scientists of what was formerly iZumi Bio with internationally-renowned scientists from top institutions such as the Harvard Stem Cell Institute and University of California San Francisco among others. iPierian is the first company to apply cellular reprogramming and directed differentiation to cells that are derived from patients representing a broad spectrum of diseases.
iPierian will apply cellular reprogramming and differentiation, including its iPS technology, to find new molecular targets and develop proprietary therapeutics for its own pipeline to treat specific diseases. iPierian is focusing on diseases for which there are poor in vivo and in vitro models and limited treatments to date. iPierian plans to initially develop a proprietary pipeline focused on three neurological disorders, including Parkinson’s disease, spinal muscular atrophy and amyotrophic lateral sclerosis. iPierian scientists have demonstrated the ability to differentiate the affected cell types in these disorders. The company is also working on calcific aortic valve disease through its collaboration with the Gladstone Institute of Cardiovascular Disease.
In addition to its proprietary pipeline, iPierian will further expand into cardiovascular and metabolic diseases through collaborations with pharmaceutical and biotechnology industry partners.
Because iPierian’s technology is based on the reprogramming of human adult somatic cells into a pluripotent state, the ethical issues specific to human embryos and human embryonic stem cells are avoided. Additionally, our disease-relevant differentiated cell lines offer numerous advantages over embryonic stem cells, particularly in the ability to reveal specific genotypes of disease, and ultimately offer a paradigm-changing technology for investigating and reclassifying major diseases by genotypic and phenotypic subtypes.
